Neuroendocrine Tumors of Pancreas

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Neuroendocrine Tumors of Pancreas Cancer

Pancreatic neuroendocrine tumors (pancreatic NETs or PNETs) account for about 7 percent of all pancreatic tumors. They may be benign or malignant and they tend to grow slower than exocrine tumors. They develop from the abnormal growth of endocrine (hormone-producing) cells in the pancreas called islet cells.

What Are the Symptoms of Neuroendocrine Tumors of Pancreas Cancer?

  • Abdominal pain
  • Jaundice, which is yellowing of the skin and whites of the eyes
  • Vomiting blood
  • Sweating
  • Rapid heart rate
  • Anxiety
  • Headache
  • Convulsions
  • Loss of consciousness
  • Clouding of vision
  • Unexplained weight gain or loss
  • Inflamed mouth and tongue
  • A mass or lump in the abdomen

Causes

No one knows what causes pancreatic NETs. People who have family members with a disorder called multiple endocrine neoplasia type 1 (MEN1), which can also affect the pancreas, are more likely to get them

Treatment

Surgery
  • Enucleation
  • Whipple procedure
  • Distal pancreatectomy
  • Splenectomy
  • Gastrectomy
Targeted therapy
  • Everolimus (Afinitor).
  • Sunitinib (Sutent)
Chemotherapy Immunotherapy

Diagnosis

  • Laboratory tests
  • Biopsy
  • Molecular testing of the tumor
  • Computed tomography (CT or CAT) scan
  • Ultrasound
  • X-ray
  • Magnetic resonance imaging (MRI)
  • Octreotide scan
  • Other imaging tests

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