Pancreatic Cancer

Pancreatic Cancer

Pancreatic Cancer is cancer which starts in the organ behind the lower part of the stomach (pancreas – gland located deep in the abdomen, between the stomach and the spine). It begins when abnormal cells in the pancreas grow and divide out of control and form a tumor. It helps to makes enzymes for digestion and hormones which could control blood sugar levels.

Some organs are made up of cells, so does pancreas. Cells divide to form new cells as per the body’s requirement. Usually, old cells died and a new cell takes the place. But sometimes the process breaks. New cells form or old cells do not die, even if the body does not need them. The extra cell may form a mass of tissue which is known as a tumor.

Few tumors are mild which means they are unnatural but cannot penetrate other parts of the body. A destructive tumor is called cancer. The cells develop out of control and can expand to other tissues and organs.

Even if cancer expands to other areas of the body, it is still called pancreatic cancer if that is where it started. It often spreads to the liver, abdominal wall, lungs, bones and/or lymph nodes.

Types of Pancreatic Cancer

Pancreatic cancer is divided into two forms:
  1. Exocrine tumors: It is the most common type of pancreatic cancer. Adenocarcinoma is the most basic type of exocrine tumor. These tumors normally start in the tubes of the pancreas, called ductal adenocarcinoma. If the tumor arises in the acini, it is called acinar adenocarcinoma.
A frequently common diagnosis is named intraductal papillary mucinous neoplasm (IPMN). An IPMN is a tumor which grows inside the pipes of the pancreas and makes a solid-fluid called mucin. IPMN is not cancerous in the beginning but if not treated early could become cancerous. Sometimes, an IPMN has already worsened and convert cancer by the time it is operated. Some rare types of exocrine pancreatic tumors are acinar cell carcinoma, adenosquamous carcinoma, colloid carcinoma, giant cell tumor, hepatoid carcinoma, mucinous cystic neoplasms, pancreatoblastoma, serous cystadenoma, signet ring cell carcinoma, solid and pseudopapillary tumors, squamous cell carcinoma, and undifferentiated carcinoma.
    1. Endocrine tumors: These are also known as pancreatic neuroendocrine tumors (PNETs) or islet cell tumors. They are not similar to exocrine tumors. A pancreatic neuroendocrine tumor functions a few times only. Only a functioning tumor makes hormones. A functioning neuroendocrine tumor is defined based on the hormone made by cells. They include: Insulinoma, Gastrinoma, Glucagonoma, Somatostatinoma, VIPomas, PPomas

Pancreatic Cancer Risk Factors

Factors which may raise a person’s risk of developing pancreatic cancer are following:

  • Age (risk of developing pancreatic cancer increases with age)
  • Gender (More females are affected rather than males)
  • Smoking & Drinking (access amount may be the cause of a pancreatic cancer in early age)
  • Obesity and diet (being overweight)
  • Diabetes
  • Family history (It’s less than one in 10%)
    1. Families with two or more first-degree relatives (parent, brother, sister or child) with pancreatic cancer
    2. Families with three or more relatives with pancreatic cancer on the same side of the family
    3. Families with a family cancer syndromeand at least one family member with pancreatic cancer. Family cancer syndromes are rare genetic conditions where a faulty gene increases the risk of pancreatic cancer.
  • Rare inherited conditions.
  • red and processed meat
  • gallstones and gall bladder surgery

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    What are the symptoms of Pancreatic Cancer?

    In the majority of cases, symptoms develop after the growth of pancreatic cancer.

    Signs of Pancreatic Cancer may include:

    • Jaundice (yellow eyes, Light-colored or greasy stools, Dark urine, itchy skin)
    • Belly(abdomen) pain or back pain
    • Weight loss and poor appetite (bloating)
    • Nausea and vomiting
    • Gallbladder or liver enlargement
    • Blood clots
    • Diabetes


    These signs usually do not mean you have Pancreatic cancer. But if you see one or more of them for more than two weeks, consult your doctor.

    How can it be diagnosed?

    Doctor may have you undergo the following tests if suspects pancreatic cancer

    • Imaging tests:  (creates pictures of your internal organs) These examinations assist your doctors to visualize your internal glands, including the pancreas. The methods used to diagnose pancreatic cancer are ultrasound, computerized tomography (CT) scans, magnetic resonance imaging (MRI) and, sometimes, positron emission tomography (PET) scans.
    • Ultrasound: (Using a scope to create pictures of your pancreas) An endoscopic ultrasound (EUS) uses an ultrasound device to take pictures of your pancreas from inside your abdomen. The device is transferred through a thin, flexible tube (endoscope) down your esophagus and into your stomach to obtain the images.
    • Biopsy: (Removing a tissue sample for testing) It is a method to extract a tiny sample of tissue for a test under a microscope. Your doctor may collect a sample of tissue from the pancreas by injecting a needle through your skin and into your pancreas (fine-needle aspiration). Or by removing a sample during EUS, guiding special tools into the pancreas.
    • Blood test. The doctors test the blood for specific proteins (tumor markers) shed by pancreatic cancer cells. The market test used in One tumor marker in pancreatic cancer is called CA19-9. There is no guarantee of the test and it is not clear how best to use the CA19-9 test results. Some doctors rank your levels throughout the treatment.

    If pancreatic cancer confirms after the diagnosis, then the Doctor determines the extent (stage) of cancer. Doctor assigns a stage of pancreatic cancer after the stage tests. It helps to decide the most likely treatments.

    Stages of Pancreatic Cancer

    Stage 0 or Carcinoma in situ: 

    The cancer is confined to the top layers of pancreatic duct cells and has not invaded deeper tissues. It has not spread outside of the pancreas. These tumors are sometimes referred to as carcinoma in situ (Tis). It has not spread to nearby lymph nodes (N0) or to distant sites (M0).

    Stage I:

    IA : The cancer is confined to the pancreas and is no bigger than 2 cm (0.8 inch) across (T1). It has not spread to nearby lymph nodes (N0) or to distant sites (M0).

    IB : The cancer is confined to the pancreas and is larger than 2 cm (0.8 inch) but no more than 4cm (1.6 inches) across (T2). It has not spread to nearby lymph nodes (N0) or to distant sites (M0).

    Stage II: 

    IIA : The cancer is confined to the pancreas and is bigger than 4 cm (1.6 inches) across (T3). It has not spread to nearby lymph nodes (N0) or to distant sites (M0).

    IIB : The cancer is confined to the pancreas and is no bigger than 2 cm (0.8 inch) across (T1) AND it has spread to no more than 3 nearby lymph nodes (N1). It has not spread to distant sites (M0).

    The cancer is confined to the pancreas and is larger than 2 cm (0.8 inch) but no more than 4cm (1.6 inches) across (T2) AND it has spread to no more than 3 nearby lymph nodes (N1). It has not spread to distant sites (M0).

    The cancer is confined to the pancreas and is bigger than 4 cm (1.6 inches) across (T3) AND it has spread to no more than 3 nearby lymph nodes (N1). It has not spread to distant sites (M0).

    Stage III:

    The cancer is confined to the pancreas and is no bigger than 2 cm (0.8 inch) across (T1) AND it has spread to 4 or more nearby lymph nodes (N2). It has not spread to distant sites (M0).

    The cancer is confined to the pancreas and is larger than 2 cm (0.8 inch) but no more than 4cm (1.6 inches) across (T2) AND it has spread to 4 or more nearby lymph nodes (N2). It has not spread to distant sites (M0).

    The cancer is confined to the pancreas and is bigger than 4 cm (1.6 inches) across (T3) AND it has spread to 4 or more nearby lymph nodes (N2). It has not spread to distant sites (M0).

    The cancer is growing outside the pancreas and into nearby major blood vessels (T4). The cancer may or may not have spread to nearby lymph nodes (Any N). It has not spread to distant sites (M0).

    Stage IV:

    The cancer has spread to distant sites such as the liver, peritoneum (the lining of the abdominal cavity), lungs or bones (M1). It can be any size (Any T) and might or might not have spread to nearby lymph nodes (Any N).

    What are the treatment options for Pancreatic Cancer?

    Your pancreatic cancer treatment at Prolife may include one or more of the following therapies:
    1. Surgery
    • Whipple procedure: A surgical method in which the head of the pancreas, the gallbladder, part of the stomach, part of the small intestine, and the bile duct are removed. Enough of the pancreas is left to produce digestive juices and insulin.
    • Total pancreatectomy: This surgery removes the whole pancreas, part of the stomach, part of the small intestine, the common bile duct, the gallbladder, the spleen, and nearby lymph nodes.
    • Distal pancreatectomy: Operation to remove pancreas body and the tail. The spleen may also be removed if cancer has spread to the spleen.
      If cancer has grown and cannot be removed, the following types of palliative surgery may be done to relieve symptoms and improve quality of life:  
    • Biliary bypass: If cancer is obstructing the bile duct and bile is building up in the gallbladder, a biliary bypass may be done. During this operation, the doctor will cut the gallbladder or bile duct in the area before the blockage and sew it to the small intestine to create a new pathway around the blocked area.
    • Endoscopic stent placement: If the tumor blocks the bile duct, an operation may be done to put in a stent (a thin tube) to drain bile that has built up in the area. The surgeon may place the stent through a catheter that drains the bile into a bag on the outside of the body or the stent may go around the blocked area and drain the bile into the small intestine.
    • Gastric bypass: If the tumor blocks the flow of food from the stomach, the stomach may be sewn directly to the small intestine so the patient can continue to eat normally.
    2. Chemotherapy Systemic Chemotherapy : drugs are used to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. When chemotherapy is taken by mouth or injected into a vein or muscle, the drugs enter the bloodstream and can reach cancer cells throughout the body.   Regional Chemotherapy : drugs are placed directly into the cerebrospinal fluid, an organ, or a body cavity such as the abdomen, the drugs mainly affect cancer cells in those areas. Combination chemotherapy :  Uses more than one anticancer drug. The way the chemotherapy is given depends on the type and stage of the cancer being treated.
    1. Targeted therapy
    It is type of treatment that uses drugs or different machines to identify and attack specific cancer cells without harming normal cells.
    1. Radiation therapy
    It uses high-energy x-rays or other types of radiation to kill cancer cells or keep them from growing. There are two types of radiation therapy:
    • External radiation therapy : A machine outside the body send a radiation toward cancer.
    • Internal radiation therapy : radioactive substance sealed in needles, seeds, wires, or catheters that are placed directly into or near cancer.
     Both depends on the type and stage of the cancer being treated.  Healing from Surgery Most people who have pancreatic cancer surgery heal without any problems. These people go home within 2-to-4 days. A fewer number of patients may have a slower recovery and need to wait for a little more. A surgeon will give you guidance on how to take care of yourself, including your surgery, bathing, driving, and sexual activity. There will be information about yourself:
    • Diet
    • Exercise
    • Pain medicine
    • Bowel movements
    After Treatment, you will be given a Daily Goals Checklist. Use that checklist to understand how you are doing every day.

    Follow-up appointments

    After you’ve completed your treatments for Pancreatic cancer, follow-up care is very essential. Routine checkups can help find any changes in your health, and if cancer comes back (or “recurs”), it can be treated as soon as possible.

    If your treatment has finished, follow-up appointments maybe every 3−6 months for the first couple of years and 6−12 months for the following 3 years.

    Your doctor may check your CEA level before you begin treatment and again after treatment to understand if it has come down.

    Doctors recommend CT scans of the chest, abdomen, and pelvis n a daily schedule for 3 years in people who are at high risk for recurrence.

    Pancreatic Cancer Statistics

    The 5-year survival rate for people with stage 4 pancreatic cancer is nearly 1 percent. This means that 1 out of every 100 people with this type of cancer are still alive 5 years after their diagnosis. Any survival rate is an estimate. Some other researchers place the 5-year survival rate at 2 percent or 3 percent.

    The risk for a person with cancer depends on many factors to a particular person

    Why choose Prolife Cancer Centre for Your Pancreatic Cancer Care?

    At Prolife Cancer Center, your Pancreatic cancer treatment is personalized to give the best results, while concentrating on your quality of life. We offer minimally invasive laparoscopic surgeries that provide successful treatment with less impact on you.

    Specialized Pancreatic Cancer Treatments

    Prolife offers unique options. Our globally renowned team of physicians shows your treatment for the most benefit while reducing the impact on your body.

    Dr. Sumit Shah is expertise in treating Pancreatic cancer. We offer the best Laparoscopic surgery treatment for pancreatic cancer also chemotherapy and targeted therapy options.

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    taha ali
    taha ali
    Consulted Dr. Sumit Shah for Cancer of Sigmoid Colon. We consulted our family physician Dr. Murtaza Saifee as my mother was complaining of abdomen pain and bleeding in her stools. Dr. Saifee sent us for further investigations. After doing her PET Scan and Colonoscopy she was diagnosed with Carcinoma of Sigmoid Colon. Dr. Saifee then referred us to Dr. Sumit Shah at Prolife Cancer Centre and Research Institute, Pune for the further treatment. Dr. Shahs expertise and knowledge in the cancer field gave us the confidence to proceed further. Dr. Sumit Shah did her surgery laparoscopic sigmoid colectomy for sigmoid colon cancer and her surgery went well. Her recovery was also quite stable and quicker than we had imagined. Also it was early stage cancer so she didn’t require any chemotherapy or radiotherapy. The entire staff at Prolife Cancer Centre took great care of her and supported her in this journey. Thankyou to Dr. Shah and his team for all that they've done for her fast recovery.
    Azhar Mulla
    Azhar Mulla
    We visited a lot of hospitals and doctors for my father's treatment but continuously failed with his treatment. That's when we came across Dr. Sumit Shah through a through Google search. Visiting Dr. Shah at Prolife Centre and Research Institute was a blessing to us. Dr. Shah's expertise in this field and positive outlook towards the patient gave us confidence in the treatment of my fathers health. My father underwent the Whipple Surgery under Dr. Shah. The surgery was successful and since then his recovery has been smooth. My father's follow up has been regular and the entire staff takes good care of his health. We sincerely express our gratitude to Dr. Shah and the entire team at Prolife Cancer Centre and Research Institute for taking care of my father and helping us out in the challenging journey. Thankyou so much.
    Kartik Rathod
    Kartik Rathod
    Dr. Sumit Shah is a lifesaver in every sense of the word and undoubtedly the best pancreatic cancer surgeon in Pune. His exceptional surgical skills and deep understanding of pancreatic cancer turned a frightening diagnosis into a story of hope and recovery for me. Dr. Shah's attention to detail, commitment to patient well-being, and ability to navigate complex procedures are truly commendable. Thanks to him, I am now enjoying a second chance at life. I can't express my gratitude enough for Dr. Shah's expertise and care. If you're seeking the finest pancreatic cancer treatment in Pune, look no further than Dr. Sumit Shah.
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    kiran sathe
    I can't thank Dr. Sumit Shah enough for his exceptional surgical skills and personalized care in pancreatic cancer treatment in Pune. Facing pancreatic cancer was daunting, but Dr. Shah's expertise put me at ease. He explained the entire treatment plan thoroughly, and the surgery he performed was a success. I highly recommend Dr. Shah, the leading Pancreatic Cancer doctor in Pune, to anyone seeking the best care for this challenging condition.
    Rangnath Pawar
    Rangnath Pawar
    Visited for pancreatic cancer My father was complaining of stomach ache in April of this year so we took him to a general physician but the pain did not subside. Then we went to an Gastroenterologist Dr. Lalit Shimpi. He investigated further. He told us to do an endoscopy and thats when we were told that he was suffering from Pancreatic Cancer. We also consulted Dr Varun Khandagale , gastroenterologist he also suggested the same. Coming from a small village Takleyali of Taluka Shirur, dist Ahamadnagar.Dr. Shimpi referred us to Dr. Sumit Shah and Prolife Cancer Centre and Research Institute, Gultekdi, Pune. We met Dr. Shah and he recommended us that we go for surgery as its the best fit for him. My father immediately underwent surgery for Carcinoma Pancreas which was done by Dr. Shah himself. Now, my father is undergoing chemotherapy at Prolife Cancer Centre and Research Institute, Gultekdi, Pune under guidance of Dr minish jain and dr shah. we continue to experience the same high level of care. We are confident that he is in the best possible hands as he fights this battle. I cannot thank Dr. Shah and the entire team enough for their expertise, professionalism, and genuine concern for their patients. Thank you all staff and doctors at prolife
    Wasim Shaikh
    Wasim Shaikh
    My brother had pain around his mouth so we consulted our family doctor. We were shocked to know that he was diagnosed with mouth Cancer after investigating further. Post diagnosis we were looking for an experienced oncologist in Pune and that's when our family doctor recommended that we come see Dr. Sumit Shah and talk about the further treatment and management. Our first impression on coming to Profile Cancer Centre and Research institute was quite good. We were all on edge on the day of our first consultation but Dr. Shah was very radiant and confident. He explained everything to us in detail and his positive attitude regarding the health of my brother pushed us to get him treated here. Right from the first day Dr. Shah's entire team took great care of my brother. He underwent surgery here at Prolife. The surgery went well and his recovery was very smooth and quicker than we expected. We really appreciate everything that Dr. Shah and his team did for my brother. Thank you so much to Dr. Shah for treating my brother with utmost care and making the whole journey an easy one for us.
    Ayyub Shaikh
    Ayyub Shaikh
    My wife had difficulty in swallowing a year back so I took the treatment of our family doctor. Her complaints were on and off but never went away. That's when our doctor investigated further and recommended us to Dr. Sumit Shah at Prolife Cancer Centre, Pune. The day we first came to meet Dr. Shah we were very scared and worried about her condition but Dr. Shah provided us the moral boost and explained to us the step by step treatment and the duration. I must say talking to Dr. Shah reduced our worries to tenfold. My wife has nodule in thyroid . She underwent surgery at prolife. Here recovery was very smooth with no change in voice . She started eating in the evening We are very happy and content to have come to him for the treatment. His patient connection and the positive attitude was a relief to me. The staff here was very cooperative and supportive. We are usually scared to go to a hospital but coming here and seeing the infrastructure and the hygiene of this hospital was a total relief to us. Everyone was so attentive and patient with us and I'm thankful to Dr. Shah and his team for taking such good care of my wife. I really appreciate the team of Prolife Centre and recommend every patient to not ignore their symptoms and directly contact Dr. Shah. Thank you so much.
    Sushma Pilane
    Sushma Pilane
    I had pain in my breast so my family doctor recommended me to Dr. Sumit Shah. Meeting him and seeing his positive attitude has given me relief. He guided me through my entire course of treatment. Talking to him has given me a positive outlook towards my symptoms. I would recommend everyone to consult Dr. Shah.

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